Step One: Reverse-Engineering the Core Tablets
Our first step was to
develop new placebo cores that matched the original tablets in weight, texture, and press profile. Without press force records or excipient specs, this meant:
- Experimental batches using multiple filler/binder systems
- Dozens of press tests using different compression forces
- Testing both flat and biconvex profiles
- Measuring friability, hardness, and disintegration to ensure base quality
We eventually settled on a viable placebo — but this was only the beginning.